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REVIEW
Year : 2017  |  Volume : 6  |  Issue : 4  |  Page : 145-153

Prospected epigenetic moderators from natural sources and drug of class NSAIDS as effective treatment options to prostate cancer


1 Volhart Health Care Pvt. Ltd., Department of Research and Development, Sitapur Road Yojna, Lucknow, UP, India
2 Faculty of Life and Health Sciences, School of Biomedical Sciences, University of Ulster, Coleraine, BT52 1SA, United Kingdom
3 Babu Banarasi Das National Institute of Technology & Management, Department of Pharmacy, Faizabad Road, Lucknow, UP, India

Correspondence Address:
Alok Semwal
Babu Banarasi Das National Institute of Technology & Management, Department of Pharmacy, Faizabad Road,Lucknow, UP
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.12980/jad.6.20170401

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Prostate cancer (PC) is one of the most common and leading cancer amongst the males all around the world. Depending upon it long latency and cost involved in its management and treatment, there is extensive need for more personalized and economical therapeutic approach for its effective therapy. The current review here discusses agents from natural dietary sources and drug class Non-Steroidal Antinflammatory (NSAIDS) that bears chemopreventive potential to regulate PC progression & tumour development and therefore could be devised into effective future treatment strategy against PC along with its metastatic castration-resistant form. Based on the literature search the therapeutic scope of selected agents are delineated, sighting their previous activity and prospects as epigenetic moderators in specific to particular PC causing biomarkers like over expression of AKR1C3, lost intracellular glutathione/glutathione-s-tranferases(GSH/GST) expression, DNA hypermethylation, aberrant cell proliferation and other related factors that are thought to potentiate and aggravate the onset of PC like smoking and use of other narcotics products.


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