| REVIEW ARTICLE |
|
| Year : 2017 | Volume
: 6
| Issue : 6 | Page : 245-254 |
|
|
Eslicarbazepine acetate: A therapeutic agent of paramount importance in acute anticonvulsant therapy
Farah Iram1, Shah Alam Khan2, Aftab Ahmad3, Anees A Siddiqui1, Asif Husain1
1 Department of Pharmaceutical Chemistry, School of Pharmaceutical Education and Research, Jamia Hamdard (Hamdard University), New Delhi-110062, India
2 Department of Pharmacy, Oman Medical College, Muscat, Sultanate of Oman
3 Health Information Technology Department, Jeddah Community College, King Abdulaziz University, P.O. Box-80283, Jeddah-21589, Kingdom of Saudi Arabia
Correspondence Address:
Asif Husain
Associate Professor, Dept of Pharmaceutical Chemistry, School of Pharmaceutical Education and Research, Hamdard University, New Delhi-110 062
India
 Source of Support: None, Conflict of Interest: None  | 2 |
DOI: 10.4103/2221-6189.221287
|
|
|
Eslicarbazepine acetate (ESL) is a new, once daily, orally administered, third generation antiepileptic drug which is indicated in the treatment of partial-onset seizures. ESL is known to exert it’s anticonvulsant effect by blocking the voltage-gated sodium channels. Several clinical trials and pharmacological studies have revealed that seizure control was better with ESL monotherapy (1 200 or 1 600 mg once daily) following a switch from other antiepileptic drugs in comparison with pseudo-placebo patients. The studies have indicated the ESL to be well tolerated and produced only mild to moderate emergent adverse events with the therapy. Being a dibenzazepine family member, structure and chemistry of ESL resembles more or less to carbamazepine and oxcarbazepine. ESL differs structurally from carbamazepine and oxcarbazepine at the 10, 11 position of dibenazepine nucleus. This molecular variation results in differences in metabolism and thus helps to prevent the formation of toxic epoxide metabolites. ESL following oral administration is rapidly metabolised to active metabolite namely S-licarbazepine which is responsible for its pharmacological activity. ESL exhibits acceptable pharmacokinetic profile and shows insignificant drug-drug interactions. In phase III clinical program, ESL was found to be efficacious and well tolerated in adult patients with partial onset seizures previously not controlled with treatment with one or two other antiepileptic drugs.
|
|
|
|
| [FULL TEXT] [PDF]* |
|
 |
|
