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REVIEW ARTICLE
Year : 2017  |  Volume : 6  |  Issue : 6  |  Page : 260-263

Acute lung injury mechanism and therapy induced by paraquat poisoning


1 Hainan Medical University, 3 Xueyuan Rd, Longhua District, Haikou City, Hainan Province, 570000, China
2 Emergency Department, The First Affiliated Hospital of Hainan Medical University, Haikou, Hainan, 570100, China

Correspondence Address:
Chuan-Zhu Lu
Emergency Department, The First Affiliated Hospital of Hainan Medical University, 31 Longhua Road, Haikou, Hainan
China
Xiao-Ran Liu
Emergency Department, The First Affiliated Hospital of Hainan Medical University, 31 Longhua Road, Haikou, Hainan
China
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/2221-6189.221289

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Paraquat (PQ, methyl viologen) was widely used in agricultural production throughout the world in 1962 for its efficient herbicidal activity. PQ was also highly toxic drug. About 5 mL medicine including 20% paraquat was life-threatening that can cause poisoning. In 1966, some people died because of PQ poisoning. Most patients had acute respiratory distress syndrome after 2 wk, and 70% of them died due to the lack of effective detoxification drugs. Thus, it was particularly important to understand the pathogenesis of PQ poisoning and give some effective treatments. This article will review the toxicological mechanism and treatment on PQ poisoning of acute lung injury.


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