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Year : 2018  |  Volume : 7  |  Issue : 1  |  Page : 20-25

Neuroprotective effects of progesterone in acute brain trauma and its physiological mechanism

1 Cartagena Neurotrauma Research Group Universidad de Cartagena, Cartagena, Colombia
2 Universidad Nacional Autonoma de Nicaragua, Managua Cartagena Neurotrauma Research Group, Universidad de Cartagena, Cartagena, Colombia
3 Department of Neurosurgery, Narayna Medical College Hospital Chinthareddypalem, Nellore-524003, Andhra Pradesh, India
4 All India Institute of Medical Science, New Delhi, India
5 Teaching Neurosurgery Hospital, Bagdad, Iraq
6 Universidad de Cartagena, Cartagena, Colombia
7 Department of Neurology, Neurosurgery Division, State University of Campinas, Campinas-Sao Paulo, Brazil

Correspondence Address:
Luis Rafael Moscote-Salazar
Neurosurgeon, Cartagena Neurotrauma Research Group, Universidad de Cartagena, Cartagena
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/2221-6189.228874

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Traumatic brain injury (TBI) is the leading cause of death and neurological disability in young adults worldwide. This work aims to review the role of progesterone in traumatic brain injury and the usefulness as a possible treatment. We searched pubmed database (2000-2017) for articles containing “progesterone and brain traumatic injury”. Basic science studies have advanced knowledge of the mechanisms of secondary brain injury, creating prospects for the medical and pharmacological management of TBI. Although several comparative studies evaluated both the efficacy and safety of several groups of drugs, in which, corticosteroids, tranexamic acid, β receptor antagonists, erythropoiesis-stimulating agents, reductase inhibitors include hydroxymethyl glutaryl-CoA inhibitors (statins), among others. Several studies even evaluated the role of progesterone in the treatment of TBI, which is providing growing evidence about its potential neuroprotective mechanisms during the acute phase of trauma. Despite recent advances in the field of management of TBI care in the emergency units, intensive care and the multiple trials for more than 20 years to find useful pharmacological treatments, most of these efforts failed in pre-clinical stages (II and III).

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