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ORIGINAL ARTICLE
Year : 2018  |  Volume : 7  |  Issue : 2  |  Page : 78-82

The experimental research on the treatment of rabbits with acute cornea alkali burn by taking bone marrow mesenchymal stem cell


Department of ophthalmology, Outpatient of Chengdu University, Chengdu, China

Correspondence Address:
Zhou Yin
Department of Ophthalmology, Outpatient of Chengdu University
China
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Source of Support: Supported by Talent Project of Chengdu University(Project number: 2081915019), Conflict of Interest: None


DOI: 10.4103/2221-6189.233016

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Objective: To study the effect of bone marrow mesenchymal stem cell(BMSCs) on angiogenesis and inflammation in rabbits with acute cornea alkali burn. Methods: New Zealand White Rabbit were chosen, while model of cornea alkali burn was made and divided into BMSCs group and control group. Rabbits in the BMSCs group were injected with BMSCs and those in the control group received PBS Solution via ear vein. Cornea turbidity and the angiogenesis area were measured at 20 d, 40 d, 60 d. The expression of angiogenic and inflammation response cytokines were measured at 60 d. Results: At 20 d, 40 d, 60 d, the cornea turbidity in BMSCs group was lower than that in control group, and the angiogenesis area in BMSCs group was smaller than that in control group; At 60 d, the mRNA expression of HIF-1 α , VEGF, MMP2, MMP9, TLR2, TLR4, IL-1α ,IL-1 β , TNF-α , ICAM-1 in cornea of BMSCs group was substantially Lower than that of control group, while BMSCs group was substantially higher than control group on mRNA expression of PEDF, TIMP1, TIMP2. Conclusions: BMSCs has inhibitory effect on angiogenesis and inflammatory response so that it is conducive to the healing of cornea alkali burn.


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