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ORIGINAL ARTICLE
Year : 2019  |  Volume : 8  |  Issue : 2  |  Page : 67-71

Polymorphism of hypoxia-inducible factor-1 α gene in pediatric acute respiratory distress syndrome


1 Kutahya Health Science University, Faculty of Medicine, Pediatric Hematology/Oncology, Evliya Celebi Yerleskesi, Tavsanlı yolu 10. km, Kutahya, Turkey
2 Yeditepe University Faculty of Medicine, Medical Genetics, Acıbadem Mah. Bağ Sok. No: 8 İstek Vakfı Binası Kadıköy Istanbul, Turkey
3 Cukurova University Faculty of Medicine, Department of Pediatric Intensive Care Unit. Çukurova Üniversitesi Tıp Fakültesi Balcalı Hastanesi 01330 Balcalı, Adana, Turkey

Correspondence Address:
Sema Yilmaz
Kütahya Health Science University, Faculty of Medicine, Department of Pediatric Hematology/Oncology, Evliya Celebi Yerleskesi, Tavsanlı yolu 10. km, Kutahya
Turkey
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/2221-6189.254429

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Objective: To examine if hypoxia-inducible factor-1 α (Hif-1 α ) polymorphisms are associated with pediatric acute respiratory distress syndrome (PARDS). Methods: Twenty two patients with PARDS and 11 non-PARDS controls were examined in pediatric intensive care unit in Cukurova University Balcali Hospital. Blood polymorphism was used to assess the Hif-1 α C1772T and G1790A polymorphisms of Hif-1 α gene, and differences in genotypes between the 2 groups were compared. Results: Hif-1 α C1772T polymorphism was observed only in one case of PARDS group but non-PARDS group didn’t show any C1772T polymorphism. Particularly, the difference in number of cases with Hif-1 α G1790A polymorphism was not significant between PARDS and non-PARDS groups. In addition, Hif-1 α G1790A polymorphism was significantly related to the distribution of lung opacities in children with PARDS (P<0.05). Conclusions: Our results indicate that Hif-1 α G1790A polymorphism is related to an increased susceptibility to pulmonary for PARDS children. The detection of G1790A polymorphism could help pediatricians to predict the extensity of PARDS early in lung tissue.


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