Comparison between Quanti-FERON-TB Gold In-Tube test and tuberculin skin test for diagnosis of latent tuberculosis in children: A cross-section study

Keyghobad Ghadiri; Alisha Akya; Maryam Janatolmakan; Mansour Rezaei; Seyed Amirabbas Sharif; Shahla Masoomshahi; Raha Khosravi; Roya chegenelorestani

doi:10.4103/2221-6189.281321

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ORIGINAL ARTICLE

Year : 2020 \| Volume : 9 \| Issue : 2 \| Page : 73-77

Comparison between Quanti-FERON-TB Gold In-Tube test and tuberculin skin test for diagnosis of latent tuberculosis in children: A cross-section study Keyghobad Ghadiri¹, Alisha Akya¹, Maryam Janatolmakan², Mansour Rezaei³, Seyed Amirabbas Sharif⁴, Shahla Masoomshahi², Raha Khosravi⁵, Roya chegenelorestani¹ ¹ Infectious Diseases Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran ² Clinical Research Development Center, Imam Reza Hospital, Kermanshah University of Medical Sciences, Kermanshah, Iran ³ Social Development and Health Promotion Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran ⁴ Infectious Diseases Research Centre, Kashan University of Medical Sciences, Kashan, Iran ⁵ Pediatric Pathology Research Center, Research Institute for Children Health, Mofid Children Hospital, Shahid Behehsti University of Medical Sciences, Tehran, Iran Correspondence Address: Roya chegenelorestani Infectious Diseases Research Center, Kermanshah University of Medical Sciences, Kermanshah Iran Source of Support: None, Conflict of Interest: None DOI: 10.4103/2221-6189.281321

Objective: To compare Quanti-FERON-TB Gold In-Tube (QFT- GIT) test and tuberculin skin test (TST) for the diagnosis of latent tuberculosis infection in children. Methods: In this cross-sectional study, 64 participants who were between 3 months and 14 years old and had close contact with smear-positive pulmonary tuberculosis were included. Both QFT- GIT test and TST were done and the results were analyzed by SPSS software and Kappa test. Results: The distribution of gender and age according to QFT-GIT and TST results were matched (P>0.05). Overall agreement between QFT-GIT and TST for diagnosis of latent tuberculosis infection in children was 75%. In addition, the contingency coefficient was 0.257, and the Kappa measure of agreement was 0.246 (P=0.034). Conclusions: Compared to TST, QFT-GIT shows no apparent advantage for diagnosis of latent tuberculosis infection in children.



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