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Management of early-onset sepsis in a teaching hospital: A descriptive retrospective study
Sana H Mohamed1, Rasha R Binni2, Bashir A Yousef3
1 Department of Clinical Pharmacy, Faculty of Pharmacy, University of Khartoum, Al-Qasr Ave, Khartoum 11111, Sudan
2 Department of Pharmacology, Faculty of Pharmacy, Sudan International University, Ebid-Khatim Street, Khartoum 11111, Sudan
3 Department of Pharmacology, Faculty of Pharmacy, Sudan International University, Ebid-Khatim Street; Department of Pharmacology, Faculty of Pharmacy, University of Khartoum, Al-Qasr Ave, Khartoum 11111, Sudan
Correspondence Address:
Bashir A Yousef
Department of Pharmacology, Faculty of Pharmacy, Sudan International University, Ebid-Khatim Street; Department of Pharmacology, Faculty of Pharmacy, University of Khartoum, Al-Qasr Ave, Khartoum 11111
Sudan
 Source of Support: None, Conflict of Interest: None
DOI: 10.4103/2221-6189.281323
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Objective: To evaluate the management of early-onset sepsis at Saad Abul-Ella Teaching Hospital, Sudan.
Methods: A descriptive retrospective hospital-based study was carried out at the Nursery Department of Saad Abul-Ella Teaching Hospital. All medical records of neonates with suspected or confirmed sepsis during the year 2017 were reviewed to evaluate the management of antibiotics for sepsis using a data collection form.
Results: Out of the 205 cases, 82 neonates (40%) were diagnosed as early-onset sepsis, among which the majority was male (68%). All neonates were given cefotaxime plus vancomycin as empirical therapy which was changed to other antibiotics in 23% of the cases. The common risk factors associated with early-onset sepsis wereprolonged rupture of membrane (41.8%), preterm delivery (26.3%) and low birth weight (15.1%). Blood cultures were performed in 168 cases, and 19% had bacterial growth of Staphylococcus aureus which is the most common isolated pathogen.
Conclusions: Cefotaxime plus vancomycin are the main empirical antibiotic for sepsis, and Staphylococcus aureus is the most common pathogen associated with early-onset sepsis.
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