• Users Online: 376
  • Print this page
  • Email this page

Table of Contents
Year : 2022  |  Volume : 11  |  Issue : 3  |  Page : 127-128

Ophthalmovigilance in COVID-19: Retinal vascular occlusion

Department of Ophthalmology, Yerevan State Medical University, Yerevan, Republic of Armenia

Date of Submission29-Mar-2022
Date of Decision12-Apr-2022
Date of Acceptance13-Jun-2022
Date of Web Publication27-Jun-2022

Correspondence Address:
Marianne Shahsuvaryan
Department of Ophthalmology, Yerevan State Medical University, Yerevan
Republic of Armenia
Login to access the Email id

Source of Support: None, Conflict of Interest: None

DOI: 10.4103/2221-6189.347782

Rights and Permissions

How to cite this article:
Shahsuvaryan M. Ophthalmovigilance in COVID-19: Retinal vascular occlusion. J Acute Dis 2022;11:127-8

How to cite this URL:
Shahsuvaryan M. Ophthalmovigilance in COVID-19: Retinal vascular occlusion. J Acute Dis [serial online] 2022 [cited 2022 Aug 8];11:127-8. Available from: https://www.jadweb.org/text.asp?2022/11/3/127/347782

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection could also cause ocular complications in 2% to 60% of infected patients. The need for an efficient COVID-19-related ocular finding detection and management pathway has sparked interest and activity in research looking for SARS-CoV-2 impact on all eye structures, especially the retina[1] that serves as an entrance gate, since retinal epithelium, arteries, and veins containing angiotensin-converting enzyme 2 represent a target for SARS-CoV-2 virus. The pathophysiological process is caused by a myriad of inflammatory reactions that damages retinal vessels through complex dysregulated functions of endothelium, platelet followed by hypercoagulability[2] manifesting as a central retinal artery (CRAO), central retinal vein occlusion (CRVO), and branch retinal vein occlusion in patients suffering from systemic polymorbidity or generally healthy without vascular risk factors, as well as young persons. It is still the case that the uncontrolled spread of COVID-19 leads to the evolution of new variants that continue to cause CRAO/CRVO[3],[4] dominantly presented by cases of retinal vein occlusion[5].

Obstruction occurs in the central retinal vein, although one or two branches of involvement may occur. Papillophlebitis as a clinical variant of CRVO in a healthy young adult with a history of recent disease and recovery of COVID-19 as the only factor of inflammation and hypercoagulability was lately evidenced[5].

In addition, in severe COVID-19 cases, bilateral CRAO and CRVO have been reported. A recent review on the subject describes retinal vascular occlusion as common among those initially without any sign of viral infection, with its subsequent development or simultaneous presentation with any degree of disease severity, or as a post-COVID. Besides, COVID-related CRAO and CRVO dominantly affect those aged 25 to 50 years, although ocular involvement may occur at any age.

Currently, available findings reflecting the consensus add more to the body of knowledge demonstrating a causal relationship between COVID-19 morbidity and retinal vascular occlusion.

At present, available findings underscore the need for ophthalmologists and health care workers to suspect such evidenced ocular comorbidity in COVID-19 cases, like CRAO/CRVO. Special attention will be paid to CRAO cases like a real emergency in ophthalmology. We suggest bearing in mind this relationship. Taking into account that retinal vessel networks represent a target for thromboembolism caused by the SARS-CoV-2, ophthalmologists should remain vigilant, especially with CRAO and CRVO patients with asymptomatic disease, and a rapid antigen test for COVID-19 should be done.

Timely detection and proper treatment of patients with vas occlusion of the retinal artery and/or vein can lessen ocular and viral disease severity, and help achieve earlier resolution on one hand, and on other hand prevent the spread of infection in health and general communities.

Conflict of interest statement

The authors report no conflict of interest.


This study received no extramural founding.

  References Top

Teo KY, Invernizzi A, Staurenghi G, Cheung CM. COVID-19-related retinal micro-vasculopathy-A review of current evidence. Am J Ophthalmol 2022; 235: 98-110.  Back to cited text no. 1
Invernizzi A. The impact of COVID-19 on the retina: Clinical features and management considerations. Exp Rev Ophthalmol 2022. doi: 10.1080/17469899.2022.2021877.  Back to cited text no. 2
Au SC, Ko CK. Prevalence of SARS-CoV-2 among central retinal artery occlusion patients: A case series-HORA study report No. 3. J Acute Dis 2021; 10(4): 147.  Back to cited text no. 3
Fonollosa A, Hernández-Rodríguez J, Cuadros C, Giralt L, Sacristán C, Artaraz J, et al. Characterizing covid-19-related retinal vascular occlusions: A case series and review of the literature. Retina 2021; 42(3): 465-475.  Back to cited text no. 4
Insausti-García A, Reche-Sainz JA, Ruiz-Arranz C, López Vázquez Á, Ferro-Osuna M. Papillophlebitis in a COVID-19 patient: Inflammation and hypercoagulable state. Eur J Ophthalmol 2022; 32(1): NP168-NP172.  Back to cited text no. 5


    Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
    Access Statistics
    Email Alert *
    Add to My List *
* Registration required (free)  

  In this article

 Article Access Statistics
    PDF Downloaded23    
    Comments [Add]    

Recommend this journal