Journal of Acute Disease

ORIGINAL ARTICLE
Year
: 2021  |  Volume : 10  |  Issue : 2  |  Page : 62--70

Clinical, laboratory and radiological features and outcomes of moderate to severe COVID-19 patients: A descriptive retrospective study


Hardeva Ram Nehara1, Sahaj Agrawal1, Atma Ram Chhimpa2, Sunil IH1, Avadusidda Arakeri1, Pramendra Sirohi1 
1 Department of Medicine, SP Medical College, Bikaner, Rajasthan, India
2 Department of Geriatric Medicine, SP Medical College, Bikaner, Rajasthan, India

Correspondence Address:
Pramendra Sirohi
Department of Medicine, SP Medical College, Bikaner, Rajasthan
India

Objective: To describe the clinical, laboratory and radiological characteristics and outcomes of moderate-to-severe coronvirus disease 2019 (COVID-19) patients. Methods: We retrospectively analyzed 43 RT-PCR confirmed moderate-to-severe COVID-19 patients who were admitted to a tertiary care center. The primary composite outcomes were admission to intensive care unit, requirement of mechanical ventilation, and death. Results: The median age of the patients was 50 years, and 62.8% of the patients were male. Out of 43 patients, 15 (34.88%) were categorized as severe. A total of 26 (60.47%) patients had 1 or more comorbidities [diabetes (34.88%) and hypertension (30.23%)]. The median duration from the onset of symptoms to admission was 3 days, and the most common symptoms were dyspnoea (90.7%), cough (79.07%), fever (69.77%), and body ache (46.51%). Leucopenia was presented in 14 (32.56%) patients, lymphopenia in 26 (60.47%) patients, and monocytosis in 7 (16.28%) patients. Besides, 40 (93.02%) patients had bilateral patchy nodular or interstitial infiltration on chest X-ray. The primary outcomes occurred in 20 patients (46.5%), among whom 8 required mechanical ventilation. The patients who had met the primary outcomes were older. They were prone to have at least 1 comorbidity (P=0.004), diabetes (P=0.01), hypertension, higher sequential organ failure assessment score, more tachycardia, lower SpO2, lower PaO2/FiO2, more thrombocytopenia, and more pancytopenia. Conclusions: This retrospective study identified several risk factors for poor outcomes in adults with COVID-19. In particular, older age, tachycardia, high SOFA score, low SpO2, low PaO2/FiO2, presence of comorbidities in form of diabetes and hypertension, thrombocytopenia, and pancytopenia at admission were associated with higher odds of ICU admission, a requirement of mechanical ventilation and in-hospital death.


How to cite this article:
Nehara HR, Agrawal S, Chhimpa AR, IH S, Arakeri A, Sirohi P. Clinical, laboratory and radiological features and outcomes of moderate to severe COVID-19 patients: A descriptive retrospective study.J Acute Dis 2021;10:62-70


How to cite this URL:
Nehara HR, Agrawal S, Chhimpa AR, IH S, Arakeri A, Sirohi P. Clinical, laboratory and radiological features and outcomes of moderate to severe COVID-19 patients: A descriptive retrospective study. J Acute Dis [serial online] 2021 [cited 2021 May 12 ];10:62-70
Available from: http://www.jadweb.org/article.asp?issn=2221-6189;year=2021;volume=10;issue=2;spage=62;epage=70;aulast=Nehara;type=0