Journal of Acute Disease

CASE REPORT
Year
: 2021  |  Volume : 10  |  Issue : 3  |  Page : 126--129

Marchiafava-Bignami disease: A case report


Monica Gupta1, Swati Garg1, Saurabh Gaba1, Rekha Gupta2 
1 Department of General Medicine, Government Medical College Hospital, Chandigarh 160030, India
2 Department of Radiodiagnosis, Government Medical College Hospital, Chandigarh 160030, India

Correspondence Address:
Monica Gupta
Department of General Medicine, Government Medical College Hospital, Chandigarh 160030
India

Rationale: Clinicians encounter multiple alcohol-related illnesses in practice, and Marchiafava-Bignami disease is a rare and devastating entity among them. It is a toxic-demyelinating disease and seen in chronic alcoholics, although it may be occasionally observed in chronically malnourished teetotalers. The clinical presentations are diverse. The symptoms and signs are non-specific, and the onset can be acute or chronic. Patient’s concerns: A 45-year-old right-handed patient suffered from alcohol use disorder with multiple non-specific neuropsychiatric manifestations. Diagnosis: Marchiafava-Bignami disease. Interventions: Thiamine, folate, vitamin B12, and steroid therapy. Outcome: The patient’s behaviour was significantly improved but dysarthria and pyramidal signs persisted. He was left with permanent cognitive impairment. Lessons: Though prompt therapy may halt the demyelinating process in this disease, the treatment remains a challenge in clinical practice. The recognition of the neuro-radiologic features is crucial to establish an early diagnosis.


How to cite this article:
Gupta M, Garg S, Gaba S, Gupta R. Marchiafava-Bignami disease: A case report.J Acute Dis 2021;10:126-129


How to cite this URL:
Gupta M, Garg S, Gaba S, Gupta R. Marchiafava-Bignami disease: A case report. J Acute Dis [serial online] 2021 [cited 2021 Jul 31 ];10:126-129
Available from: http://www.jadweb.org/article.asp?issn=2221-6189;year=2021;volume=10;issue=3;spage=126;epage=129;aulast=Gupta;type=0