REVIEW ARTICLE
Year : 2022 | Volume
: 11 | Issue : 6 | Page : 212--221
Non-vitamin K antagonist oral anticoagulants for COVID-19 thrombosis
Adel Khalifa Sultan Hamad
Department of Electrophysiology, Mohammed bin Khalifa bin Salman Al Khalifa Cardiac Centre, Awali, Kingdom of Bahrain
Correspondence Address:
Adel Khalifa Sultan Hamad
Department of Electrophysiology, Mohammed bin Khalifa bin Salman Al Khalifa Cardiac Centre, Awali
Kingdom of Bahrain
Thrombotic complications appear to be a major predictor of death in COVID-19 patients, and multiple studies have shown that anticoagulants can help to improve the outcome. The Food and Drug Administration’s acceptance of non-vitamin K antagonist oral anticoagulants (NOACs) has sparked much excitement about their potential as a replacement for existing oral anticoagulants. NOACs target a single clotting factor, often activated factor X or thrombin, and involve the coagulation factor Xa inhibitors including apixaban, edoxaban, and rivaroxaban, and the thrombin inhibitor dabigatran. COVID-19 is an infectious disease that causes thrombotic events by inducing a pro-inflammatory and prothrombotic condition. This article provides a comprehensive overview of the mechanism behind enhanced thrombogenicity accompanying COVID-19, the clinical range of NOACs, and the role of NOACs in treatment of COVID-19 based on recent investigations and clinical trials.
How to cite this article:
Hamad AK. Non-vitamin K antagonist oral anticoagulants for COVID-19 thrombosis.J Acute Dis 2022;11:212-221
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How to cite this URL:
Hamad AK. Non-vitamin K antagonist oral anticoagulants for COVID-19 thrombosis. J Acute Dis [serial online] 2022 [cited 2023 Mar 27 ];11:212-221
Available from: https://www.jadweb.org/article.asp?issn=2221-6189;year=2022;volume=11;issue=6;spage=212;epage=221;aulast=Hamad;type=0 |
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