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ORIGINAL ARTICLES
Knowledge, attitude, and practice towards coronavirus disease 2019 (COVID-19) among medical students: A cross-sectional study
Sonam Maheshwari, Puneet Kumar Gupta, Richa Sinha, Pravesh Rawat
May 2020, 9(3):100-104
DOI
:10.4103/2221-6189.283886
Objective:
To assess knowledge, attitude, and practice of medical students towards coronavirus disease 2019 (COVID-19).
Methods:
A self-designed questionnaire was developed and given to the students of a government medical college in Uttarakhand. The demographics, mean knowledge, attitude, and practice of the participants were investigated, and the scores were calculated. t-test and ANOVA were used for statistical analysis.
Results:
Out of the total participants (n=354), 50.3% were male and 54.5% were 21-23 years. Almost all the participants (96.6%) increase the frequency of washing hands under the influence of COVID-19. Although no significant relationship was found between different religions, age-categories in terms of knowledge, the participants who were aged 21-23 years had higher knowledge. In addition, gender had a significant impact on practice scores (P<0.05) while no demographic variable was found to have a significant relation with attitude score (P>0.05).
Conclusions:
The majority of the participants had good knowledge, positive attitude, and sufficient practice. Females and males have significantly different practices. Although the results are very positive, it is suggested that people should continue to strengthen knowledge, attitude, and practice towards COVID-19, so that India can win the battle against the disease.
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14
20,207
1,843
PERSPECTIVES
Minimizing the risk of international spread of coronavirus disease 2019 (COVID-19) outbreak by targeting travelers
Saurabh R Shrivastava, Prateek S Shrivastava
March 2020, 9(2):47-48
DOI
:10.4103/2221-6189.278654
The Coronavirus Disease-2019 (COVID-19) outbreak has become a global health emergency owing to its magnitude, attributed deaths, and its propensity to spread across the world. In-fact, owing to its quick spread across international boundaries and the resulting caseload, the disease has been declared as a Public Health Emergency of International Concern on 30 January 2020. It is worth noting that out of the 395 cases detected in other nations, 165 (41.8%) have a positive history of travel to China. As of now, the World Health Organization has not recommended for any restrictions on the travel or trade aspects, but has clearly specified that implementation of International Health Regulations should be strictly done at the airports and seaports. In conclusion, the COVID- 19 outbreak has created an alarm across the globe as the causative virus is novel in nature. However, strengthening of standard infection control practices and adoption of preventive measures for travelers can significantly minimize the threat of further transmission of the disease.
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7
2,051
371
ORIGINAL ARTICLES
Diminazene aceturate modified nanocomposite for improved efficacy in acute trypanosome infection
Oluwatosin Kudirat Shittu, Shaba Yisa Aaron, Mariam Damilola Oladuntoye, Bashir Lawal
January 2018, 7(1):36-42
DOI
:10.4103/2221-6189.228876
Objective:
To investigate the improved antitrypanocidal activity and toxicity of diminazene aceturate modified Nano drug in experimental rats.
Methods:
Aqueous leaf extract of
Hyptis suaveolens
was used to reduce gold tetrachloride to its nanoparticle size and this was characterized and formulates with naturally synthesized polyhydroxybutyrateas a Nano carrier. A total of thirty
[30]
albino rats were group into 6 (A-F) of 5 rats each & infected intraperitoneally with 0.2 mL of the inoculum containing about 1x10
3
Trypanosoma brucei brucei
parasites per 0.2 mL of blood. Groups A and B were treated with 3 and 6 minutes released orange PHB, Groups C and D were treated with 15 and 30 minutes released mango PHB formulated tablet while Groups E and F were negative (untreated) and standard drug (Dininazene aceturare) respectively.
Results:
The free drug and modified orange synthesized polyhydroxy butyrate shows antitrypanocidal activities by reducing the replicating rate of the parasite as compared to infect untreated. While the modified- mango synthesized shows increasing order of replication. There were significant increases in all the haematological parameter evaluated in the infected treated groups compared to infect untreated. But no significant difference (
P
<0.05) observed in the Catalase activity in the serum and liver of all the groups whereas, the modified orange synthesized shows significant decrease in other enzymes activities evaluated when compared with the free drug, mango synthesized and the infected untreated groups.
Conclusion:
Orange synthesized modified diminazene aceturate show efficacy as free drug with limited toxicity that can enhance the therapeutic.
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1,890
235
Integron frequency of
Escherichia coli
strains from patients with urinary tract infection in Southwest of Iran
Miaad K Alkhudhairy, Morteza Saki, Sakineh Seyed–Mohammadi, Nabi Jomehzadeh, Saeed Khoshnood, Mina Moradzadeh, Sajjad Yazdansetad
May 2019, 8(3):113-117
DOI
:10.4103/2221-6189.259110
Objective:
To investigate the frequency of integrase genes
intI1, intI2
and
intI3
of
Escherichia coli
strains, and their association with resistance to routinely used antibiotics.
Methods:
A total of 120
Escherichia coli
strains were collected from patients with urinary tract infection in Ahvaz, Southwest of Iran. Antibiotic susceptibility testing was performed. The presence of
intI1, intI2
, and
intI3
genes was determined by polymerase chain reaction.
Results:
Antibiotic susceptibility testing disclosed the highest resistance rate to ampicillin (91.7%) followed by trimethoprim/sulfamethoxazole (65.8%), and ceftazidime (56.7%). The imipenem susceptibility rate was 91.7%.
IntIl
and
intI2
were identified in 74 (61.6%) and 8 (6.6%) of
Escherichia coli
strains, respectively, but
intI3
was not found in any isolates. The presence of integrons was significantly associated with resistance to ampicillin, trimethoprim/ sulfamethoxazole, ceftazidime, and ciprofloxacin antibiotics (
P
<0.05).
Conclusions:
The high resistant
Escherichia coli
isolates harboring class 1 integrons
(intI1)
were detected in patients with urinary tract infection in our region. Therefore, preventive strategies are necessary to restrict further dissemination of resistant strains.
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4
2,052
302
REVIEW ARTICLES
Biomarkers in acute brain trauma: A narrative review
GA Quinones-Ossa, H Padilla-Zambrano, R Pal, A Ghosh, LR Moscote-Salazar, VA Kiran Kumar, A Agrawal
January 2019, 8(1):1-6
DOI
:10.4103/2221-6189.250370
Biomarkers have been used to diagnose, prognose, evaluate, and identify the severity and outcomes in traumatic brain injury (TBI) patients. This study explored if it is possible to predict the outcome of TBI patients by estimating the biomarkers in cerebrospinal fluid and serum. We searched data bases and literature about biomarkers, and found forty epidemiologic studies from 92 potentially relevant articles. However, limited data are available about postanoxic encephalopathy. It showed that presently, neurofilament, S100B, glial fibrillary acidic protein, and ubiquitin carboxyl terminal hydrolase-L1 seemed to have the best potential as diagnostic biomarkers for distinguishing focal and diffuse injury, whereas C-Tau, neuron-specific enolase, S100B, glial fibrillary acidic protein, and spectrin breakdown products appear to be candidates for reflective biomarkers of TBI. Point-of-care biomarkers are needed in TBI which is one of the most important additional risk factors in road traffic injuries. In a holistic approach, more researches about biomarkers of TBI are required. These biomarkers are very useful for treatment of patients with TBI.
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4
2,255
406
ORIGINAL ARTICLES
Protective effects of
Aristolochia longa
and
Aquilaria malaccensis
against lead induced acute liver injury in rats
Derouiche Samir, Zeghib Khaoula, Gharbi Safa, Khelef Yahia, Feriani Anouar
September 2017, 6(5):193-197
DOI
:10.4103/2221-6189.219611
Objective:
To investigate the protective effects of
Aristolochia longa (A. longa)
and
Aquilaria malaccensis (A. malaccensis)
on acute hepatotoxicity induced by lead in female albino rats.
Methods:
Twenty five (25) apparently healthy female Wistar rats were randomly divided into five groups of five rats in each: control, Pb, Pb +
A. longa
(Ar), Pb+
A. malaccensis
(Aq), and Pb+
A. longa
(Ar) +
A. malaccensis
(Aq) lead (100 mg/kg b.w.) as Pb (C
2
H
3
O
2
)
2
added in their drinking water for 75 days.
A. longa
(rhizome powder at a dose of 10 g/kg of diet) and
A. malaccensis
(heartwood powder at a dose 10 g/kg of diet) were added to the feed during the last 15 days of lead exposed in the animals.
Results:
Obtained results revealed that lead treatment caused a significant increase in serum GOT, GPT and ALP activities and in liver of MDA level and CAT activity. In contrast, it led to an decrease in the liver GOT, GPT and GST activities and in GSH level in rats. Also, the results clearly showed that lead causes alterations of hepatic tissue in comparison with controls. Our results showed that treatment with
A. malaccensis
and A. longa a partial correction of the previous parameters. The histological observations confirmed the hepatoprotection results by the biochemical parameters.
Conclusions:
Results demonstrated beneficial effects of
A. longa
and
A. malaccensis
treatment in Pb-induced oxidative stress and tissue damage in liver.
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2,650
345
Acute otitis media with facial nerve palsy: our experiences at a tertiary care teaching hospital of eastern India
Santosh Kumar Swain, Alok Das, Jatindra Nath Mohanty
September 2019, 8(5):204-207
DOI
:10.4103/2221-6189.268410
Objective:
To assess acute otitis media with facial nerve paralysis, its prognosis, and treatment.
Methods:
It is a retrospective study. Thriteen patients of acute otitis media associated with facial nerve paralysis attended the outpatient department of otorhinolaryngology between May 2017 and April 2019. All patients were clinically assessed with appropriate investigations, prognosis, and treatment.
Results:
Out of 13 patients, 2 were identified with complete facial paralysis and the remaining 11 patients presented with incomplete paralysis. Medical treatment including antibiotics and corticosteroids failed, while myringotomy and facial nerve decompression were done with a favorable outcome. Eleven patients recovered to grade-I (House-Brackmann) and 2 cases to grade-II (House-Brackmann).
Conclusion:
Peripheral facial nerve paralysis in acute otitis media is rare. Antibiotics and steroids yield good outcome as conservative management. In case of failure by conservative treatment, facial nerve decompression yields a favorable outcome.
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2,860
226
REVIEW ARTICLE
A review of
Acanthamoeba
keratitis in the middle East and Iran
Mohammad Hossein Feiz Haddad, Azar Shokri, Habib Habibpour, Seyede Manizhe Heidar Nejadi
July 2019, 8(4):133-141
DOI
:10.4103/2221-6189.263705
Acanthamoeba
keratitis, a vision-threatening disease, is caused by a free-living amoeba of genus
Acanthamoeba
. Amoeba is widely distributed all around the world. Several cases of
Acanthamoeba
keratitis have been reported from the Middle East and Iran as well. The infection is mainly caused by inappropriate use of contact lens; therefore, it is more common among lens wearers. The number of reported cases worldwide is increasing annually due to the increasing number of contact lens wearers for medical or cosmetic reasons. It is known that early diagnosis and treatment can reduce consequent damages, while the delay in these processes will deteriorate the vision. Nowadays contact lens wearing, surgery and use of corticosteroids are known to predispose to
Acanthamoeba
keratitis, and it was also believed that trauma was the main cause. Increasing public knowledge about
Acanthamoeba
infection, inquiring the history of patients, clinical signs and laboratory findings can be helpful to early diagnosis and better treatment. Regardless of the increasing knowledge of diagnosis and treatment, this disease is still a challenge. Considering the long curative time, and insufficient efficacy of available treatments, it seems that the prevention is more important than the treatment. This review aimed to explain
Acanthamoeba
keratitis in the Middle East and Iran from the aspects of epidemiology, diagnosis, and therapeutic treatment.
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3
2,698
340
REVIEW ARTICLES
The chest X ray in pulmonary embolism: Westermark sign, Hampton's Hump and Palla's sign. What's the difference?
Tan Si Hong Shawn, Lim Xin Yan, Fatimah Lateef
May 2018, 7(3):99-102
DOI
:10.4103/2221-6189.236822
Pulmonary embolism (PE), with the incidence of about 60 per 100 000 annually, can be a life- threatening disease if it is not treated promptly. It has been estimated that some 10% of PE patients die within the first hour of the event. Untreated PE has a mortality of about 30%. PE is a condition that is treatable if suspected and diagnosed early. The chest radiograph is still the first investigation that is ordered in patients presenting with cardiorespiratory symptoms or symptoms suggestive of PE. The CXR is also helpful in identifying or excluding other conditions or diagnoses. Thus, knowing and understanding some of the more specific CXR signs can be useful. We suggest that physicians to be aware of and utilize CXR findings such as Palla's sign, Westermark sign and Hamptons hump to help with the diagnosis of PE and to exclude other conditions that can mimic venous thrombo-embolism. Even if these signs are not common, their presence, even in an unsuspected patient without a high pretest probability of PE, should prompt further investigations such as a D-dimer test, lung scintigraphy or computed tomography pulmonary angiography as required.
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3
28,575
1,428
CASE REPORT
A severe case of levothyroxine intoxication successfully treated in intensive care unit
Yusuf Savran, Tugce Mengi, Merve Keskinkilic
August 2018, 7(4):175-177
DOI
:10.4103/2221-6189.241029
Levothyroxine intoxication is a rare clinical entity which is usually asymptomatic. However, severe symptoms such as respiratory failure, malignant hyperthermia, seizures, arrhythmia, and coma have been reported. In this case report, a patient who ingested high dose (15 mg) levothyroxine for suicide and admitted to intensive care unit was presented. There was a decrease in Glasgow coma score in the follow-up. The patient was intubated due to acute respiratory failure. Gastric lavage, activated charcoal, methylprednisolone, cholestyramine and therapeuthic plasma exchange were administered. Despite ingestion of high dose of levothyroxine, thyrotoxicosis symptoms resolved with appropriate treatment and the patient was discharged from the intensive care unit.
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2
12,276
467
CASE REPORTS
Unusual form of strongyloidiasis with gastric involvements: A case report
Soheil Ebrahimpour, Mahmoud Sadeghi–Haddad–Zavareh, Zeinab Darabi Ahangar, Zeinab Mohseni Afshar, Zeinab Sheidaie, Parisa sabbagh, Arefeh Babazadeh
May 2019, 8(3):127-129
DOI
:10.4103/2221-6189.259114
Rationale:
Strongyloides stercoralis (S. stercoralis)
is an intestinal nematode with a complicated life cycle that can involve the gastrointestinal system. Infected patients are generally asymptomatic; but if symptomatic, the symptoms will include skin rash, respiratory and gastrointestinal symptoms like abdominal pain, diarrhea, nausea and vomiting.
Patient concerns:
A 77-year old man presented with edema of the lower extremities and insignificant tenderness in the epigastric region.
Diagnosis:
The histopathology of gastric tissue showed severe inflammation and multiple ulcers in the cardia, antrum and proximal duodenum. A large number of rhabditiform larvae of
S. stercoralis
along with tissue hyperemia and infiltration of lymphoplasma cells, eosinophils, and neutrophils were found.
Intervention:
Treatment with albendazole.
Outcome:
Despite the albendazole treatment, the patient’s condition deteriorated and eventually died because of a sepsis-like syndrome.
Lesson:
Physicians should remain alert to the urgency due to threadworm, especially among the elderly people and immunosuppressed cases; and should ensure accurate diagnosis, suitable treatment and careful follow-up of these cases.
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2
1,644
321
Necrotizing fasciitis of lower extremity due to diverticulitis perforation: a case report
Halil Dogan, Bilginar Kovanci
May 2019, 8(3):130-132
DOI
:10.4103/2221-6189.259115
Rationale:
Necrotizing fasciitis is an aggressive infection of subcutaneous tissues, which tends to spread rapidly through the fascial planes. Colonic diverticulosis is a common disease in advanced age, although it rarely causes a lethal necrotizing soft-tissue infection.
Patient concerns:
A 58-year-old woman complained of left leg pain for 15 d without abdominal pain.
Diagnosis:
Diverticulitis perforation presented as necrotizing fasciitis of the left thigh.
Interventions:
Extensive debridement.
Outcomes:
The patient died due to sepsis-induced multiple organ failure and severe metabolic acidosis.
Lessons:
Clinicians should be aware of presentations of diverticulitis in patients who have a soft-tissue infection in lower extremity even though patients may not have had a history of diverticulosis or abdominal pain.
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2
1,469
226
ORIGINAL ARTICLES
Earthquake planning and crisis management with an emphasis on the facilities, utilities, and services of the health care centers of Tiran and Karvan County, Isfahan Province, Iran: A case study
Rouhullah Dehghani, Narges Mohammadzadeh, Maryam Salehi, Hamid Kassiri
May 2018, 7(3):115-121
DOI
:10.4103/2221-6189.236825
Objective:
To study earthquake planning and crisis management with an emphasis on the facilities, utilities, and services of the health care centers of Tiran and Karvan County, Isfahan Province.
Methods:
This is a descriptive-analytical survey based on the quantitative and qualitative characteristics of Tiran and Karvan County Health Care Centers(HCCs). Twenty quantitative and qualitative indicators were derived from the studied HCCs and analyzed using the strengths, weaknesses, opportunities and threats analysis technique. The top crisis management strategies were identified and a number of strategies and solutions were proposed.
Results:
The HCC utilities such as water, electricity, gas, and heating and cooling systems were in average condition, whereas the facilities of the majority of HCCs were in vulnerable-to-average condition. In addition, they sustained relatively high degree of instability which calls for reassessment and effective policies to minimize weaknesses and eliminate threats using strengths and opportunities.
Conclusions:
It is recommended that the condition of Tiran and Karvan County HCCs be enhanced by distributing new HCCs based on the population density, expanding the road network and creating vast, wide-open spaces to enable field hospital construction in times of crisis.
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2
2,872
271
Virulence determinants and biofilm formation in clinical isolates of
Enterococcus
: A cross-sectional study
Fatemeh Shahi, Hajar Hamidi, Saeed Khoshnood, Golshan Mehdipour, Aram Asarezadegan Dezfouli, Ahmad Farajzadeh Sheikh
January 2020, 9(1):27-32
DOI
:10.4103/2221-6189.276079
Objective:
To evaluate the relationship between biofilm formation and incidence of virulence determinants in clinical isolates of
Enterococcus
.
Methods:
In this cross-sectional study, the clinical isolates of
Enterococcus
strains were collected from the university teaching hospitals in Ahvaz, Iran from June 2017 to June 2018. Then, the prevalence of
Enterococcus
species, antibiotic resistance, virulence factors, and biofilm-producing ability were determined.
Results:
Of the 119 tested isolates, 17 (14.3%) were
Enterococcus faecalis
, 72 (60.5%) were
Enterococcus faecium
and 30 (25.2%) were other
Enterococcus
spp. Gelatinase was detected in 97 (81.5%) isolates, enterococcal surface protein in 41 (34.5%) isolates, serine protease in 39 (32.8%) cases, accessory colonization factor in 111 (93.3%) cases and pathogenicity islands in 17 (14.3%) cases. The biofilm formation ability was observed in 75 (63.0%) of all isolates and the association between the presence of enterococcal surface protein gene and biofilm formation was statistically significant. Higher resistance to vancomycin, gentamycin, and teicoplanin was indicated in
Enterococcus faecium
with 81.8%, 58.4%, and 85.7% resistance rate, respectively. All
Enterococcus faecalis
isolates were sensitive to teicoplanin and vancomycin.
Conclusions:
The presence of antibiotic-resistance with several virulence factors in
Enterococcus
spp has become a concern. High prevalence of enterococcal surface protein gene among biofilm- producing isolates suggests a potential relation between biofilm formation and the enterococcal surface protein gene, and further studies are needed to identify the mechanism of biofilm inhibition.
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2
1,557
260
PERSPECTIVES
Resorting to mathematical modelling approach to contain the coronavirus disease 2019 (COVID-19) outbreak
Saurabh R Shrivastava, Prateek S Shrivastava
March 2020, 9(2):49-50
DOI
:10.4103/2221-6189.281311
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2
1,172
289
REVIEW ARTICLES
Acute lung injury mechanism and therapy induced by paraquat poisoning
Xian-Li Liu, Xiao-Ran Liu, Chuan-Zhu Lu
November 2017, 6(6):260-263
DOI
:10.4103/2221-6189.221289
Paraquat (PQ, methyl viologen) was widely used in agricultural production throughout the world in 1962 for its efficient herbicidal activity. PQ was also highly toxic drug. About 5 mL medicine including 20% paraquat was life-threatening that can cause poisoning. In 1966, some people died because of PQ poisoning. Most patients had acute respiratory distress syndrome after 2 wk, and 70% of them died due to the lack of effective detoxification drugs. Thus, it was particularly important to understand the pathogenesis of PQ poisoning and give some effective treatments. This article will review the toxicological mechanism and treatment on PQ poisoning of acute lung injury.
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2
2,674
373
The laparoscopic approach in emergency surgery: A review of the literature
Ionut Negoi, Mircea Beuran, Cezar Ciubotaru, Adelina Cruceru, Sorin Hostiuc, Massimo Sartelli, Matthew Hernandez, Mihaela Vartic
January 2018, 7(1):15-19
DOI
:10.4103/2221-6189.228873
The role of laparoscopy in the acute care surgery had significantly increased during the latest years, both as a diagnostic and treatment method of all the upper or lower gastrointestinal pathologies. The objective of the present research is to review the current indications for laparoscopy in bdominal emergencies and to detail the benefits and complications associated with this approach. We have reviewed the relevant literature about this topic published between January 2005 and December 2017, using the PubMed/Medline and Web of Science Core Collection databases. According to the current evidence, we may conclude that the laparoscopic approach is an integral part of the emergency surgery for all the abdominal pathologies. Although laparoscopy requires specialized training and curricula, it brings all the benefits of minimal access in acute care arena.
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2
3,528
456
A review on
Acinetobacter baumannii
Xin Wang, Li-Jie Qin
January 2019, 8(1):16-20
DOI
:10.4103/2221-6189.250373
Acinetobacter baumannii
is a major cause of nosocomial infections worldwide. By summarizing the epidemiology, molecular and drug resistance mechanisms, diagnosis and treatment strategies of Acinetobacter baumannii, the clinical outcome is finally improved.
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2
3,368
719
CASE REPORTS
Intracranial hematoma development following thrombolysis inpatients suffering with acute myocardial infarction: Management strategy
Luis Rafael Moscote Salazar, Amit Agrawal, Guru Dutta Satyarthee, George Chater Cure, Alfonso Pacheco-Hernandez
October 2018, 7(5):217-219
DOI
:10.4103/2221-6189.244174
Intracerebral hemorrhage secondary to thrombolysis in patients with acute myocardial infarction is a catastrophic condition. Several factors predispose to intracranial bleeding including low body weight, female sex, advanced age, use of oral anticoagulants prior to the administration of fibrinolytic therapy, diastolic blood pressure (greater than 110 mm Hg), among others. Optimal medical management involves multidisciplinary roles of hematology, neurosurgery and critical medicine. In this illustrative case, a classification and management algorithm were proposed for patients with complications hemorrhage associated with thrombolysis after myocardial infarction.
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1
1,831
249
Acute pancreatitis with cytomegalovirus infection in a kidney transplant recipient: A case report
Zeinab Mohseni Afshar, Arefeh Babazadeh, Soheil Ebrahimpour, Sima Golmohammadi
January 2019, 8(1):43-44
DOI
:10.4103/2221-6189.250379
Cytomegalovirus (CMV) can cause significant inflammation. Besides, it is an important cause of pancreatitis in organ transplantations. We report a case of CMV pancreatitis in a 48-year-old male kidney transplant recipient who was admitted with elevated amylase (3 337 U/L) and lipase (1 160 U/L) enzymes, and abdominal pain. CMV infection was tested by reverse transcription polymerase chain reaction and the result was positive. CMV viremia was successfully cleared with ganciclovir. Then the absence of some of more noticeable clinical symptoms of pancreatitis may not be a decisive reason not to rule out the disease in transplanted cases.
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1,581
248
ORIGINAL ARTICLES
Seroprevalence of acute human parvovirus B19 viraemia among anaemic children in ibadan city, Nigeria
Odunayo Rahmat Ajagbe, GN Odaibo, Olaniyan Oluwaseun, Idris Abdullahi Nasir
November 2018, 7(6):254-257
DOI
:10.4103/2221-6189.248024
Objective:
To determine the seroprevalence of B19V IgM as a measure of acute infection and associated risk factors among < 5 years children at Oyo state, Nigeria.
Methods:
One hundred and sixteen (116) and thirty eight (38) blood samples were individually collected from severe anaemia and age-matched non-anaemic children between 1-60 months old at Oyo state, Nigeria. EDTA anticoagulated blood was tested for their packed cell volume, while sera were tested for human parvovirus IgM antibodies using microhaematocrit centrifuge and Enzyme Linked Immunosorbent Assay, respectively. Interviewer-based questionnaires were used to collect participants' sociodemographic variables.
Results:
Anti-B19V IgM was detected in 17 (14.7%) severe anaemia subjects, whereas, only 2 (5.3%) non-anaemia subjects had B19V IgM. The prevalence of parvovirus B19 IgM antibodywas higher in anaemic subjects than non-anaemic control group. There is significant association between the seroprevalence of anti-B19V IgM and family size (
P
=0.001), number of siblings (
P
=0.032) and education status (
P
=0.01) of anaemic children but seroprevalence of anti-B19V IgM is not significantly associated with gender, family type and age (
P
>0.05).
Conclusions:
The seroprevalence of 14.7% among anaemic children confirm that these infections are endemic in Nigeria. This level of infectivity suggests that there is a high risk of transmission to healthy children as well as children with underlying haemolytic or acquired anaemia in Nigeria.
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1,498
195
Safety assessment of
Chlorophytum alismifolium
tuber extract (Liliaceae): Acute and sub-acute toxicity studies in Wistar rats
Abdulhakim Abubakar, Abdullahi Balarabe Nazifi, Fatima Ismail Hassan, Kehinde Andem Duke, Theophillus Danjuma Edoh
January 2019, 8(1):21-27
DOI
:10.4103/2221-6189.250374
Objective:
To explore the toxicological profile of methanol extract of
Chlorophytum alismifolium
(MECA) tubers in Wistar rats.
Methods:
MECA was subjected to acute and sub-acute studies which were conducted according to Organization for Economic Co-operation and Development (OECD 425 and 407 guidelines respectively). In the acute toxicity experiment, a limit test (5 000 mg/kg) was administered to five rats and monitored for 2 weeks. The sub-acute studies were conducted on 4 groups of rats. The first group served as control, while the 2
nd
, 3
rd
and 4
th
groups received MECA (150, 300 and 600 mg/kg respectively). The treatments were given orally and daily for 4 weeks. At the end of the experiment (29
th
day), the animals were euthanized to obtain blood samples and organs for haematological, biochemical and histological evaluations.
Results:
Acute toxicity study showed that the oral median lethal dose was >5 000 mg/kg. In the sub-acute studies, the results showed no significant (
P
>0.05) changes in the haematological, hepatic and renal indices compared to control animals. In the fourth week, a significant (
P
<0.01) increase in body weight of the rats was observed at 150 mg/kg and 600 mg/kg compared to week one. However, there were no major changes in the organ/ body weights of the rats. Histological examination of the kidney showed slight glomerular adhesion and tubular distortion. Moderate hepatic necrosis was observed at 150 mg/kg and 300 mg/kg.
Conclusions:
The results of this research revealed that the MECA tubers is virtually non-toxic after acute administration and it has low sub-acute toxicity potential in rats.
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1,993
296
Systemic analysis of pre-hospital trauma emergency treatment in Zhengzhou
Xiao-Peng Shi, Li-Jie Qin, Yu-Xia Chang, Fa-Liang Li, Peng Wang
January 2019, 8(1):34-37
DOI
:10.4103/2221-6189.250376
Objective:
To analyze the data of pre-hospital emergency treatment in zhengzhou from 2007 to 2016, and evaluate the current situation of pre-hospital trauma emergency treatment, in order to provide a scientific basis for effective use of first aid resources and enhance success rate of trauma emergency treatment.
Methods:
Retrospective analysis was conducted based on pre-hospital emergency resources of Zhengzhou Emergency Medical Rescue Center from 2007 to 2016.
Results:
The total number of pre-hospital emergency treatment cases was 9 305 687 from 2007 to 2016 in Zhengzhou, of which 418 882 were trauma cases. The top five causes of injury were traffic accident injury, cutting injury, beating injury, crushing injury and falling injury. The top five emergency treatments used were oxygen, hemostasis, dressing and fixation, fluid supplementation, analgesics and sputum aspiration. According to different directions of diagnosis, the pre-hospital emergency patients were divided into four groups: emergency treatment group, emergency observation group, admission to general ward group and admission to ICU group. There was no statistical difference in the ages among the four groups (
P
>0.05). There were significantly statistical differences in gender composition among the four groups, with more males than females (
P
<0.01). Significant statistical differences also showed in CRAMS scores among the four groups (
P
<0.01). Before and after the training of primary trauma care, there was no significant difference in the constituent ratio of the trauma (
P
>0.05), but the mortality of the trauma, the average arrival time, and the mean treatment time were significantly different (
P
<0.01).
Conclusions:
The number of pre-hospital emergency trauma patients increased year by year, but the constituent ratio changed little. CRAMS score is important for the patients triage. Through the training of primary trauma care, the constituent ratio of death was reduced, and the average treatment time was shortened.
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1,617
254
Survival rate among tuberculosis patients identified in south of Iran, 2005-2016
Vahid Rahmanian, Karamatollah Rahmanian, Narges Rahmanian, Mohammad Ali Rastgoofard, Elham Mansoorian
October 2018, 7(5):207-212
DOI
:10.4103/2221-6189.244172
Objective:
To determine the survival rate of tuberculosis (TB) patients and to identify the important factors associated with the survival of these patients in southern Iran.
Methods:
The present retrospective cohort study extracted and reviewed available medical records of 134 TB patients undergoing TB treatment centre, during 2005 to 2016. The Survival rate of patients for the outcome of the interval from diagnosis until death was plotted using life table and Kaplan-Meier survival curve. Cox proportional hazard regression model was used to examine the simultaneous effect of variables on survival rate. The significance level was considered to be 0.05.
Results:
In this study, 64.2% of the participants were male, 73.1% had pulmonary TB and 5.22% had HIV. The survival rate of one, five and thirteen years after diagnosis were 93%, 78% and 69%, respectively. The risk of death in patients with extrapulmonary TB (95%
CI
=1.96-15.83,
P
=0.001) was 5.58 times higher than in patients with pulmonary TB. The risk of death in smokers with TB (95%
CI
=1.74-2.46,
P
<0.001) was 2.07 times higher than in non-smoker patients, and also the risk of death increased to 1.10 times more for a one-year increase in patient age (95%
CI
=1.06-1.14,
P
<0.001).
Conclusions:
The risk of death in patients with extrapulmonary TB and TB smokers was higher than other patients. Therefore, timely diagnosis and proper treatment of patients with extrapulmonary TB as well as the development and integration of smoking cessation programs are underlined and emphasized in the formulation and implementation of the National Tuberculosis Control Program.
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1
2,037
281
Triazinone herbicide metribuzin induced acute liver injury: A study of animal model
Derouiche Samir, Rezzag mohcen Om Selma, Serouti Asma
August 2018, 7(4):152-157
DOI
:10.4103/2221-6189.241016
Objective:
To evaluate the acute toxicity effect of metribuzin at low dose on liver of mother rabbits and its fetus.
Methods:
Pregnant female rabbits
Oryctolagus cuniculus
were divided into three groups (
n
=5). The first group of non-treated pregnancy rabbits served as control; the second group of pregnancy rabbits were treated with 1/100 LD
50
of metribuzin and the third group of pregnancy rabbits were treated with 1/50 LD
50
of metribuzin. Metribuzin was added in their drinking water for 60 d before and during pregnancy. Levels of liver malondialdehyde, liver glutathione S transferase, serum glutamic oxalacetic transaminase and serum glutamic- pyruvic transaminase were determined. Liver reduced glutathione level was also determined by a colorimetric method. And hepatic homogenate was analyzed by HPLC analysis to determine the existence of traces of metribuzin.
Results:
Results revealed a significant increase in level of liver malondialdehyde, glutathione S transferase, serum glutamic oxalacetic transaminase and serum glutamic-pyruvic transaminase activities in mother and fetuses rabbits of both metribuzin treatment groups as compared to the control group. However the level of reduced glutathione was decreased in mother and fetuses rabbits of both groups treated with metribuzin compared to control group. Also, the results obtained by HPLC technique showed the presence of trace metribuzin in liver cells of mothers and fetuses rabbits of the both metribuzin treated groups.
Conclusions:
In conclusion, this study shows that exposure to metribuzin at low concentrations causes a acute toxicity in liver of mother rabbits and its fetus, also the trace of the metribuzin detected in the liver is the origin of possible malformation of the fetuses or abortion of the rabbits.
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2,146
229
* Source: CrossRef
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th
Sep 2017.